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In a cell, nanometer-sized molecules (that’s a billionth of a meter) dynamically self-organize to form structures and transmit information across cellular length scales, accomplishing changes in membrane shape, cell division, and whole cell motility. Actin is a highly abundant, self-organizing protein that forms long, higher-ordered polymers. When polymerization is coordinated in space and time against a membrane surface, it provides the force required to move cells and organelles and structurally support membranes.

Molecular mechanisms of motility: We explore basic mechanisms of cell motion and the role of actin-based structures in moving membranes. We are particularly interested in how cells decide where and when to construct dendritic actin networks in processes such as cellular and organelle motility.

The role of actin inside organelles: While much is known about how actin networks are assembled on the cytoplasmic face of organelle membranes, actin has also been found inside organelles where its role is far more mysterious. Specifically, we are interested in investigating its role in the mitochondrial matrix.

Quantitative Microscopy: Imaging is a powerful tool to study cellular processes and mechanisms. We develop methods to extract more quantitative information from microscopy data sets through custom code, machine learning, and the creation of new image processing pipelines.

Check our our (skruber-lab.com) for more detailed information about our lab, on-going research, potential projects, publications, and courses.